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中科院分子病毒与免疫重点实验室
2009-07-15 02:57:00 来源: 打印 关闭

  一.实验室简介 

  中国科学院分子病毒与免疫重点实验室(2010DP173064)在2010年12月由中科院正式批准成立,依托单位为中科院上海巴斯德研究所。现任学术委员会主任为曹雪涛院士,实验室主任为唐宏研究员,副主任为张晓明、江陆斌、金侠研究员。

   中科院分子病毒学与免疫学重点实验室坚持“三个面向”,致力于病毒免疫学的基础和应用基础研究,通过原始创新,发现病原-宿主互作新机制,寻找抗病毒感染新靶标,为传染病防控提供新思路与策略。

  二.学术委员会 

  主任

  曹雪涛(中国医学科学院/协和医科大学 中国工程院院士 教授) 

    委员:

    刘小龙(中科院上海生科院生物化学与细胞研究所 研究员)

    魏于全(四川大学 中国科学院院士 教授)

    田志刚(中国科技大学 教授)

    熊思东(苏州大学 教授)

    黎孟枫(中山大学 教授)

    陈新文(中科院武汉病毒研究所 研究员)

    夏宁邵(厦门大学 教授)

    唐 宏(中科院上海巴斯德研究所 研究员)

    肖 晖(中科院上海巴斯德研究所 研究员)

    金 侠(中科院上海巴斯德研究所 研究员)

  三.研究队伍 

  目前实验室根据3个研究方向,共设置了23个研究组。研究组名称如下: 

  1. 病毒学:病毒的急慢性感染机制及相关基础研究 

     分子病毒学研究组 组长:孙兵 研究员 

     抗感染研究组 组长:艾德铭(Ralf Altmeyer研究员 

     肿瘤病毒研究组 组长:蓝柯 研究员 

     病毒性肝炎研究组 组长:钟劲 研究员 

     结构病毒学研究组 组长:陈荣 研究员 

     病毒免疫学研究组 组长:王建华 研究员 

     疱疹病毒分子生物学研究组 组长:钱志康 研究员 

     病毒与淋巴瘤研究组 组长:梁小珍 研究员 

     病毒组装与宿主研究组 组长:龙钢 研究员 

  2.免疫学:阐明病毒与宿主细胞之间的相互作用的分子机制 

     分子免疫学研究组 组长:李斌 研究员 

     抗结核免疫与防治研究组 组长:陈维政 研究员 

     免疫调节研究组 组长:冷启彬 研究员 

     造血干细胞与转基因动物研究组 组长:张岩 正高级工程师 

     天然免疫学研究组 组长:孟广勋 研究员 

     免疫信号传导与调节研究组 组长:肖晖 研究员 

     呼吸道感染病理研究组 组长:苏枭 研究员 

     天然防御和免疫调控研究组 组长:张晓明 研究员 

  3.疫苗学基础研究与应用基础研究 

     抗病毒免疫与遗传治疗研究组 组长:周保罗 研究员 

     疫苗学与抗病毒策略研究组 组长:黄忠 研究员 

     抗感染免疫与疫苗研究组 组长:周东明 研究员 

     病毒疾病与疫苗转化研究组 组长:金侠 研究员 

     人体寄生虫分子和细胞生物学研究组 组长:江陆斌 研究员 

     病原真菌感染及宿主免疫研究组 组长:陈昌斌 研究员 

  

  

四.研究成果   

2013 

  1.Liu Q, Huang X, Ku Z, Wang T, Liu F, Cai Y, Li D, Leng Q, Huang Z*.Characterization of enterovirus 71 capsids using subunit protein-specific polyclonal antibodies. J Virol Methods. 2013 Jan;187(1):127-31.Epub 2012 Oct 6.

  2.Hu W, Chen A, Miao Y, Xia S, Ling Z, Xu K, Wang T, Xu Y, Cui J, Wu H, Hu G, Tian L, Wang L, Shu Y, Ma X, Xu B, Zhang J, Lin X*, Bian C*, Sun B*. Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient. Virology. 2013 Jan 20;435(2):320-8 Epub 2012 Oct 16

  3.Xia T, Lévy L, Levillayer F, Jia B, Li G, Neuveut C, Buendia MA, Lan K*, Wei Y*. The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor β (TGF-β) signalling by regulating ubiquitination of the E3 ligase Arkadia. J Biol Chem. 2013 Jan 18;288(3):1785-94. Epub 2012 Dec 4.

  4.Liu L, Wang W, Yang L, Ren H, Kimata JT, Zhou P*. Trimeric GPI-anchored HCDR3 of Broadly Neutralizing Antibody PG16 is a Potent HIV-1 Entry Inhibitor. J Virol. 2013 Feb;87(3):1899-905. Epub 2012 Nov 14.

  5.Mao K, Chen S, Chen M, Ma Y, Wang Y, Huang B, He Z, Zeng Y, Hu Y, Sun S, Li J, Wu X, Wang X, Strober W, Chen C*, Meng G*, Sun B*. Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res.2013 Feb;23(2):201-12.

  6.Qian M, Hu H, Zuo T, Wang G, Zhang L, Zhou P*. Unravel a Neutralization Mechanism by Two Human Antibodies against Conserved Epitopes in the Globular Head of H5 Hemagglutinin.J Virol. 2013 Mar;87(6):3571-7.

  7.Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, Gao Z, Pan L, Tao L, Wen C, Yao Z, Tsun A, Shi G*, Li B*. Identification of the E3 deubiquitinase USP21 as a positive regulator of GATA3. J Biol Chem. 2013 Feb 10. [Epub ahead of print]

  8.Chen Z, Luo X, Lu Y, Zhu T, Wang J, Tsun A*, Li B*. Ubiquitination signals critical to regulatory T cell development and function. Int Immunopharmacol. 2013 Feb 14. 2013.01.023.

  9.Ku Z, Ye X, Huang X, Cai Y, Liu Q, Li Y, Su Z, Huang Z* Neutralizing Antibodies Induced by Recombinant Virus-Like Particles of Enterovirus 71 Genotype C4 Inhibit Infection at Pre- and Post-attachment Steps. PLoS One. 2013;8(2):e57601. Epub 2013 Feb 22.

  10.Shi J, Huang X, Liu Q, Huang Z*.Identification of conserved neutralizing linear epitopes within the VP1 protein of coxsackievirus A16. Vaccine. 2013 Mar 13.

  11.Cai Y, Liu Q, Huang X, Li D, Ku Z, Zhang Y*, Huang Z*. Active immunization with a Coxsackievirus A16 experimental inactivated vaccine induces neutralizing antibodies and protects mice against lethal infection. Vaccine. 2013 Mar 13.

  12.Liu W, Qin Y, Bai L, Lan K, Wang JH*. Kaposi's-sarcoma-associated-herpesvirus-activated dendritic cells promote HIV-1 trans-infection and suppress CD4+ T cell proliferation. Virology. 2013 Mar 16.

  13.Ding Q, Cao X, Lu J, Huang B, Liu YJ, Kato N, Shu HB, Zhong J*. Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity. J Hepatol. 2013 Jul;59(1):52-8 

  14.Wang H, Xing Y, Mao L, Luo Y, Kang L, Meng G*. Pannexin-1 influences peritoneal cavity cell population but is not involved in NLRP3 inflammasome activation. (communication) Protein Cell. 2013 Apr;4(4):259-65.  

  15.Lei G, Chen M, Li H, Niu JL, Wu S, Mao L, Lu A, Wang H, Chen W, Xu B, Leng Q, Xu C, Yang G, An L, Zhu LP, Meng G*.Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome. (letter) Cell Res. 2013 Jul;23(7):965-8. 

  16.Wang Y, Yang C, Mao K, Chen S, Meng G, Sun B. Cellular localization of NLRP3 inflammasome.Protein Cell. 2013 Jun;4(6):425-31 

  17. Li Y, Tsun A, Gao Z, Han Z, Gao Y, Li Z, Lin F, Wang Y, Wei G, Yao Z, Li B. TIP60 Positively Regulates ThPOK-Mediated Repression of Eomesodermin in Human CD4+ T Cells. J Biol Chem. 2013 May 31;288(22):15537-46 

  18. Zhou P, Wang Z, Yuan X, Zhou C, Liu L, Wan X, Zhang F, Ding X, Wang C, Xiong S, Wang Z, Yuan J, Li Q, Zhang Y. Mixed Lineage Leukemia 5 (MLL5) Regulates Cell Cycle Progression and E2F1-responsive Gene Expression via Association with Host Cell Factor-1 (HCF-1). J Biol Chem. 2013 Jun 14;288(24):17532-43 

  19. Zhai RR, Jiang AP, Wang HB, Ma L, Ren XX, Jiang JF, Wu L, Wei JF, Wang JH. Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells. Virology  2013 Aug 1;442(2):163-72  

  20. Lu J, Tao W, Li R, Xiang Y, Zhang N, Xiang X, Xie Q, Zhong J*.Construction and characterization of infectious hepatitis C virus chimera containing structural proteins directly from genotype 1b clinical isolates.Virology. 2013 Aug 15;443(1):80-8 

  21.Li HY, Han JF, Qin CF, Chen R., Virus-like particles for enterovirus 71 produced from Saccharomyces cerevisiae potently elicits protective immune responses in mice. Vaccine. 2013 Jul 11;31(32):3281-7  

  22.Zhang H, Hale BG, Xu K, Sun B*. Viral and Host Factors Required for Avian H5N1 Influenza A Virus Replication in Mammalian Cells. Viruses. 2013 Jun 10;5(6):1431-46. 

  23.Wang H, Mao L, Meng G*.The NLRP3 inflammasome activation in human or mouse cells, sensitivity causes puzzle. Protein Cell. 2013 Aug;4(8):565-8. 

  24.Wang G, Zhou F, Buchy P, Zuo T, Hu H, Liu J, Song Y, Ding H, Tsai C, Chen Z, Zhang L, Deubel V, Zhou P. DNA Prime and Virus-like Particle Boost From a Single H5N1 Strain Elicits Broadly Neutralizing Antibody Responses Against Head Region of H5 Hemagglutinin. J Infect Dis. 2014 Mar;209(5):676-85    

  25.Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B. The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3. Immunity. 2013 August 22; 39(2) :272-85  

  26.Wei R, Xu L, Zhang N, Zhu K, Yang J, Yang C, Deng C, Zhu Z, De Groot AS, Altmeyer R, Zeng M, Leng Q. Elevated antigen-specific Th2 type response is associated with the poor prognosis of hand, foot and mouth disease. Virus Res. 2013 Oct;177(1):62-5.  

  27.Shan Z, Han Q, Nie J, Cao X, Chen Z, Yin S, Gao Y, Lin F, Zhou X, Xu K, Fan H, Qian Z, Sun B, Zhong J, Li B, Tsun A. Negative Regulation of Interferon-Induced Transmembrane Protein 3 by SET7-mediated Lysine Monomethylation. J Biol Chem. 2013 Dec 6;288(49):35093-103  

  28.Qi Y, Xiang Y, Wang J, Qi Y, Li J, Niu J, Zhong J. Inhibition of hepatitis C virus infection by polyoxometalates. Antiviral Res. 2013 Sep 8;100(2):392-398.  

  29.Jiang L, Mu J, Zhang Q, Ni T, Srinivasan P, Rayavara K, Yang W, Turner L, Lavstsen T, Theander TG, Peng W, Wei G, Jing Q, Wakabayashi Y, Bansal A, Luo Y, Ribeiro JM, Scherf A, Aravind L, Zhu J, Zhao K, Miller LH. PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum. Nature. 2013 Jul 11;499(7457):223-7.  

  30.Ye X, Ku Z, Liu Q, Wang X, Shi J, Zhang Y, Kong L, Cong Y, Huang Z. Chimeric virus-like particle vaccines displaying conserved enterovirus 71 epitopes elicit protective neutralizing antibodies in mice through divergent mechanisms. J Virol. 2014 Jan;88(1):72-81 

  31.Xu Y, Li H, Chen W, Yao X, Xing Y, Wang X, Zhong J, Meng G. Mycoplasma hyorhinis Activates the NLRP3 Inflammasome and Promotes Migration and Invasion of Gastric Cancer Cells. PLoS One. 2013 Nov 6;8(11):e77955 

  32.Mao L, Zhang L, Li H, Chen W, Wang H, Wu S, Guo C, Lu A, Yang G, An L, Abliz P, Meng G. Pathogenic Fungus Microsporum canis Activates the NLRP3 Inflammasome. Infect Immun. 2014 Feb;82(2):882-92.  

  33.Hu W, Chen A, Miao Y, Xia S, Ling Z, Xu K, Wang T, Xu Y, Cui J, Wu H, Hu G, Tian L, Wang L, Shu Y, Ma X, Xu B, Zhang J, Lin X, Bian C, Sun B. Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient. Virology. 2013 Jan 20;435(2):320-8.     

  34.Lu J, Xiang Y, Tao W, Li Q, Wang N, Gao Y, Xiang X, Xie Q, Zhong J. A novel strategy to develop robust infectious hepatitis C virus cell culture system directly from a clinical isolate. J Virol. 2014 Feb;88(3):1484-91.   

  35.Zhao C, Su EM, Yang X, Gao Z, Li L, Wu H1, Jiang Y, Su X. Important Role of Platelets in Modulating Endotoxin-Induced Lung Inflammation in CFTR-Deficient Mice. PLoS One. 2013 Dec 19;8(12):e82683.     

  36.Lyu K, Ding J, Han JF, Zhang Y, Wu XY, He YL, Qin CF, Chen R Human Enterovirus 71 Uncoating Captured at Atomic Resolution. J Virol. 2014 Mar;88(6):3114-26.     

  37.Wang Z, Zhu K, Bai W, Jia B, Hu H, Zhou D, Zhang X, Zhang X, Xie Y, Mancini-Bourgine M, Michel ML, Lan K, Deng Q. Adenoviral Delivery of Recombinant Hepatitis B Virus Expressing Foreign Antigenic Epitopes for Immunotherapy of Persistent Viral Infection. J Virol. 2014 Mar;88(5):3004-15.     

  38.Chen W, Xu Y, Li H, Tao W, Xiang Y, Huang B, Niu J, Zhong J, Meng G. HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells. PLoS One. 2014 Jan 6;9(1):e84953. 

 

  2012  

  1.Li YZ, Counor D, Lu P, Liang GD, Huong VT, Nga PT, Loan HT, Sun G, Grandadam M, Butrapet S, Lavergne JP, Flamand M, Yu YX, Solomon T, Buchy P, Deubel V*.A specific and sensitive antigen capture assay for NS1 protein quantitation in Japanese encephalitis virus infection.J Virol Methods. 2012 Jan;179(1):8-16. Epub 2011 Jun 15

  2.He Y, Weng L, Li R, Li L, Toyoda T,  Zhong J*.The N-terminal helix α(0) of hepatitis C virus NS3 protein dictates the subcellular localization and stability of NS3/NS4A complex.Virology. 2012 Jan 20;422(2):214-23.

  3.Gao Y, Lin F, Su J, Gao Z, Li Y, Yang J, Deng Z, Liu B, Tsun A, Li B*.Molecular mechanisms underlying the regulation and functional plasticity of FOXP3(+) regulatory T cells.Genes Immun. (Review)2012 Jan;13(1):1-13

  4.Wang K, Lu W, Chen J, Xie S, Shi H, Hsu H, Yu W, Xu K, Bian C, Fischer WB, Schwarz W, Feng L*, Sun B* PEDV ORF3 encodes an ion channel protein and regulates virus production..FEBS Lett. 2012 Feb 17;586(4):384-91. Epub 2012 Jan 11.

  5.Liu Y, Sun R, Lin X, Liang D, Deng Q, Lan K*.KSHV-encoded miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5.J Virol. 2012 Feb;86(3):1372-81.

  6.Hongxing Hu, Jarrod Voss, Guoliang Zhang, Philippi Buchy, Teng Zuo, Lulan Wang, Feng Wang, Fan Zhou, Guiqing Wang, Cheguo Tsai, Lesley Calder, Steve J.  Gamblin, Linqi Zhang, Vincent Deubel, Boping Zhou, John J. Skehel and Paul Zhou*. A Human Antibody Recognizing a Conserved Epitope of H5 Hemagglutinin Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses.J Virol.2012 Mar;86(6):2978-89. Epub 2012 Jan 11.

  7.Xu C, Hu WB, Xu K, He YX, Wang TY, Chen Z, Li TX, Liu JH, Buchy P, Sun B*. Amino acids 473V and 598P of PB1 from an avian origin influenza A virus contribute to polymerase activity especially in mammalian cells.J Gen Virol.  2012 Mar;93(Pt 3):531-40.

  8.Weng L, Kohara M, Wakita T, Shimotohno K, Toyoda T*. Detergent-induced activation of the hepatitis C virus genotype 1b RNA polymerase.Gene.2012 Apr 1;496(2):79-87.Epub 2012 Jan 28.

  9.Jin Y, He Z, Liang D, Zhang Q, Zhang H, Deng Q, Robertson ES, Lan K*.LANA Carboxyl Terminal Amino Acids 1052 to 1082 Interact with RBP-Jκ and are Responsible for LANA-Mediated RTA Repression.J Virol. 2012 May;86(9):4956-69. Epub 2012 Feb 29.

  10.Zhou F, Wang G, Buchy P, Cai Z, Chen H, Chen Z, Cheng G, Wan XF, Deubel V, Zhou P*.A Tri-Clade DNA Vaccine Designed on the Basis of a Comprehensive Serologic Study Elicits Neutralizing Antibody Responses against All Clades and Subclades of HPAI H5N1 Viruses.J Virol.2012 Jun;86(12):6970-8. Epub 2012 Apr 11

  11.Xiaomin Song, Bin Li, Yan Xiao, Chunxia Chen, Qiang Wang, Yujie Liu, Alan Berezov, Chen Xu,Yayi Gao, Zhiyuan Li, Shiaw-Lin Wu, Zheng Cai,Hongtao Zhang, Barry L. Karger, Wayne W. Hancock, Andrew D. Wells, Zhaocai Zhou*, and Mark I. Greene* Structural and biological features of FOXP3 dimerization relevant to regulatory T Cell function. Cell Rep. 2012 Jun 28;1(6):665-75. Epub 2012 Jun 15.

  12.Li Y, Counor D, Lu P, Duong V, Yu Y, Deubel V*. Protective immunity to Japanese encephalitis virus associated with anti-NS1 antibodies in a mouse model. Virol J. 2012 Jul 24;9:135.

  13.Yang L, Song Y, Li X, Huang X, Liu J, Ding H, Zhu P, Zhou P*. HIV-1 Virus Like Particles Produced by Stably Transfected Drosophila S2 cells - a Desirable Vaccine Component. J Virol. 2012 Jul;86(14):7662-76. Epub 2012 May 2.

  14.Tian RR, Guo HX, Wei JF, Yang CK, He SH*, Wang JH*. IFN-lambda inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral production. Antiviral Res. 2012 Jul;95(1):57-65. Epub 2012 May 11.

  15.Qin Y, Li YY, Jiang AP, Jiang JF, Wang JH*. Stimulation of Cryptococcus neoformans isolated from skin lesion of AIDS patient matures dendritic cells and promotes HIV-1 trans-infection.Biochem Biophys Res Commun.  2012 Jul 13;423(4):709-14. Epub 2012 Jun 12.

  16.Sun J, Yu Y, Deubel V*.Japanese encephalitis virus NS1' protein depends on pseudoknot secondary structure and is cleaved by caspase during virus infection and cell apoptosis.Microbes Infect. 2012 Sep;14(11):930-40. Epub 2012 Mar 28.

  17.Ding Q, Huang B, Lu J, Liu YJ and Zhong J*, Hepatitis C Virus NS3/4A protease blocks IL-28 production. Eur. J. Immunol. 2012 Sep;42(9):2374-82

  18.Liu Q, Yan K, Feng Y, Huang X, Ku Z, Cai Y, Liu F, Shi J, Huang Z*. A virus-like particle vaccine for coxsackievirus A16 potently elicits neutralizing antibodies that protect mice against lethal challenge. Vaccine. 2012 Oct 19;30(47):6642-8. 2012 Sep 7 Epub

  19.Wang Q, Weng L, Jiang H, Zhang S, Toyoda T*.Fluorescent primer-based in vitro transcription system of viral RNA-dependent RNA polymerases. Anal Biochem. 2012 Oct 24;433(2):92-94.Epub 2012 Oct 24.

  20.Wang L, Hu H, Yang J, Wang F, Kaisermayer C, Zhou P*. High Yield of Human Monoclonal Antibody Produced by Stably Transfected Drosophila Schneider 2 Cells in Perfusion Culture Using Wave Bioreactor. Mol Biotechnol. 2012 Oct; 52(2):170-9

  21.Shen CJ, Jia YH, Tian RR, Ding M, Zhang C, Wang JH*. Translation of Pur-α is targeted by cellular miRNAs to modulate the differentiation-dependent susceptibility of monocytes to HIV-1 infection.FASEB J. 2012 Nov;26(11):4755-64, Epub 2012 Jul 26.

  22.Ku Z, Shi J, Liu Q, Huang Z*.Development of murine monoclonal antibodies with potent neutralization effects on enterovirus 71. J Virol Methods. 2012 Dec;186(1-2):193-7.2012 Jul 4. [Epub ahead of print]

  23.Lin X, Li X, Liang D, Lan K*.miRNAs and usRNAs Discovered in Kaposi's Sarcoma-associated Herpesvirus Virions. J Virol. 2012 Dec;86(23):12717-30,Epub2012 Sep 12.

  24.Gao Z, Gao Y, Li Z, Chen Z, Lu D, Tsun A*, Li B*.Synergy between IL-6 and TGF-β signaling promotes FOXP3 degradation.Int J Clin Exp Pathol. 2012;5(7):626-33.

  25.Wei R, Yang C, Zeng M, Terry F, Zhu K, Yang C, Altmeyer R, Martin W, De Groot AS, Leng Q*. A Dominant EV71-Specific CD4+ T Cell Epitope Is Highly Conserved among Human Enteroviruses. PLoS One. 2012;7(12):e51957. Epub 2012 Dec 14.

  2011 

  1.Deguang Liang, Yuan Gao, Xianzhi Lin, Zhiheng He, Qinglan Zhao, Qiang Deng,Ke Lan*   A human herpesvirus miRNA attenuates interferonsignaling and contributes to maintenance    of viral latency bytargeting IKKε Cell Res.,2011 May;21(5):793-806. Epub 2011 Jan 11

  2.Xianzhi Lin, Deguang Liang, Zhiheng He, Qiang Deng, Erle S. Robertson, Ke Lan* miR-K12-7-5p Encoded by Kaposi’s Sarcoma-Associated Herpesvirus Stabilizes the Latent State by Targeting Viral ORF50/RTA Plos One, 2011,6(1):e16224

  3.Jiang H, Weng L, Zhang N, Arita M, Li R, Chen L, Toyoda T*Biochemical characterization of enterovirus 71 3D RNA polymerase. Biochim Biophys Acta. 2011 Mar;1809(3):211-9. Epub 2011 Jan 8.

  4.Ding H, Tsai C, Gutiérrez RA, Zhou F, Buchy P, Deubel V, Zhou P.* Superior Neutralizing Antibody Response and Protection in Mice Vaccinated with Heterologous DNA Prime and Virus Like Particle Boost against HPAI H5N1 Virus PLoS One.2011 Jan 28;6(1):e16563.

  5.Liu Q, Ku Z, Cai Y, Sun B, Leng Q, Huang Z.* Detection, characterization and quantitation of Coxsackievirus A16 using polyclonal antibodies against recombinant capsid subunit proteins. J Virol Methods.2011 Apr;173(1):115-20. Epub 2011 Feb 3

  6.Xu K, Ling ZY, Sun L, Xu Y, Bian C, He Y, Lu W, Chen Z, Sun B*.Broad humoral and cellular immunity elicited by a bivalent DNA vaccine encoding HA and NP genes from an H5N1 virus. Viral Immunol. 2011 Feb;24(1):45-56

  7.Hao X, Shang X, Wu J, Shan Y, Cai M, Jiang J, Huang Z*, Tang Z*, Wang H*. Single-Particle Tracking of Hepatitis B Virus-like Vesicle Entry into Cells. Small. 2011 May 9;7(9):1212-8. doi: 10.1002/smll.201002020. Epub 2011 Mar 24

  8.Ding H, Tsai C, Zhou F, Buchy P, Deubel V, Zhou P*. Heterosubtypic Antibody Response Elicited with Seasonal Influenza Vaccine Correlates Partial Protection against Highly Pathogenic H5N1 Virus PLoS One. 2011 Mar 25;6(3):e17821.

  9.Li X, Liang D, Lin X, Robertson ES, Lan K*.Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65. J Virol. 2011 Sep;85(17):8606-15. Epub 2011 Jun 22

  10.Liu L, Wen M, Wang W, Wang S, Yang L, Liu Y, Qian M, Zhang L, Shao Y, Kimata JT, Zhou P*.Potent and broad anti-HIV-1 activity exhibited by a GPI-anchored peptide derived from the CDR H3 of broadly neutralizing antibody PG16. J Virol.2011 Sep;85(17):8467-76. Epub 2011 Jun 29.

  11.Xie S, Wang K, Yu W, Lu W, Xu K, Wang J, Ye B, Schwarz W, Jin Q, Sun B*. DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71. Cell Res.(letter) 2011 Aug;21(8):1271-5.Epub 2011 Jul 12.

  12.Deng C, Yang C, Wan J, Zhu L, Leng Q* Irregular poliovirus vaccination correlates to pulmonary edema of hand, foot and mouth disease. Clin Vaccine Immunol.(Letter) 2011 Sep;18(9):1589-90. Epub 2011 Jul 13.

  13.Yang C, Deng C, Wan J, Zhu L, Leng Q*.Neutralizing antibody response in the patients with hand, foot and mouth disease to enterovirus 71 and its clinical implications.Virol J.2011 Jun 16;8:306.

  14.Wang K, Deubel V*. Mice with different susceptibility to Japanese encephalitis virus infection show selective neutralizing antibody response and myeloid cell infectivity.PLoS One. 2011;6(9):e24744. Epub 2011 Sep 16.

  15.Tsun A, Li YY, Li B*.You, me and Foxp3: immune regulation for two.Immunotherapy.(Review) 2011 Oct;3(10):1139-42.

  16.Tsun A, Chen Z, Li B*.Romance of the three kingdoms: RORgammat allies with HIF1alpha against FoxP3 in regulating T cell metabolism and differentiation. Protein Cell.(Review)2011 Oct;2(10):778-81.

  17.Jiang H, Xu Y, Li L, Weng L, Wang Q, Zhang S, Jia B, Hu H, He Y, Jacob Y, Toyoda T*.Inhibition of influenza virus replication by constrained peptides targeting nucleoprotein.Antivir Chem Chemother. 2011 Nov 17;22(3):119-30.

  18.Qin Y, Li Y, Liu W, Tian R, Guo Q, Li S, Li H, Zhang D, Zheng Y, Wu L, Lan K, Wang J*. Penicillium marneffei-Stimulated Dendritic Cells Enhance HIV-1 Trans-Infection and Promote Viral Infection by Activating Primary CD4 T Cells. PLoS One. 2011;6(11):e27609.

  19.Liu F, Liu Q, Cai Y, Leng Q, Huang Z*. Construction and characterization of an infectious clone of coxsackievirus A16.Virol J.2011 Dec 13;8(1):534.

  20.Mingkuan Chen, Hongbin Wang, Wei Chen and Guangxun Meng* Regulation of Adaptive Immunity by the NLRP3.Inflammasome Int.Immunopharmacol. (Review), 2011 May;11(5):549-54. Epub 2010 Nov 27.

  21.Zuojia Chen, Fang Lin, Yayi Gao, Zhiyuan Li, Jing Zhang, Yue Xing, Zihou Deng, Zhengju  Yao,Andy Tsun, Bin Li*. FOXP3 and RORγt: Transcriptional regulation of Treg and Th17. Int.Immunopharmacol.(Review), 2011 May;11(5):536-42. Epub 2010 Nov 23

  22.Ke Xu, Christoph Klenk, Bin Liu, Bjoern Keiner, Jinke Cheng, Bo-Jian Zheng, Li Li,Qinglin Han, Chen Wang, Tianxian Li, Ze Chen, Yuelong Shu, Jinhua Liu, Hans-Dieter Klenk,* and Bing Sun* Modification of nonstructural protein 1 of influenza A virus by SUMO1.J Virol. 2011 Jan;85(2):1086-98. Epub 2010 Nov 3,[Epub ahead of print]

  23.Rui Li, Yan Qin, Ying He, Wanyin Tao, Nan Zhang, Cheguo Tsai, Paul Zhou , Jin Zhong* Production of hepatitis C virus lacking the envelope-encoding genes for single-cycle infection by providing homologous envelope proteins or vesicular stomatitis virus glycoproteins in trans. J Virol. 2011 Mar;85(5):2138-47. Epub 2010 Dec 15.

  24.Xiaogang Xiang, JieLu, ZhixiaDong, HuijuanZhou , WanyinTao, QingGuo, XiaqiuZhou, Shisan Bao , QingXie*, JinZhong* Viral sequence evolution in Chinese genotype 1b chronic hepatitis C patients experiencing unsuccessful interferon treatment. Infect.Genet. Evol. 2011 Mar;11(2):382-90. Epub 2010 Dec 13.

  2010 

  1.Zhang S, Weng L, Geng L, Wang J, Zhou J, Deubel V, Buchy P, Toyoda T*. Biochemical and Kinetic analysis of the influenza virus RNA polymerase purified from insect cells. Biochem. Biophys. Res. Commun. 2010, 391: 570-574

  2.He Z, Liu Y, Liang D, Wang Z, Robertson ES, Lan K. Cellular corepressor TLE2 inhibits replication-and- transcription-activator-mediated transactivation and lytic reactivation of Kaposi’s sarcoma-associated herpesvirus J Virol. 2010 Feb;84(4):2047-62. Epub 2009 Nov 25.(IF:5.15)

  3.Asako Murayama., Leiyun Weng., Tomoko Date, Daisuke Akazawa, Xiao Tian, Tetsuro Suzuki, Takanobu Kato, Yasuhito Tanaka, Masashi Mizokami, Takaji Wakita*, Tetsuya Toyoda* RNA polymerase activity and specific RNA structure are required for efficient HCV replication in cultured cells. PloS Path. 2010,6(4): e1000885

  4.He Y, Xu K, Keiner B, Zhou J, Czudai V, Li T, Chen Z, Liu J, Klenk HD, Shu YL, Sun B*. Influenza A virus replication induces cell cycle arrest in G0/G1 phase J Virol. 2010 Dec, 84(24):12832-40.Epub 2010 Sep 22

  5.Weng L, Hirata Y, Arai M, Kohara M, Wakita T, Watashi K, Shimotohno K, He Y, Zhong J, Toyoda T*. Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype specific manner. J Virol. 2010,84(22):11761-70

  6.Zhang S, Wang J, Wang Q, Toyoda T*. Internal initiation of influenza virus replication of v-and cRNAin vitro. J. Biol. Chem. 2010 Dec 24;285(52):41194-201. Epub 2010 Sep 20.

  7.Michael Wen, Reetakshi Arora, Huiqiang Wang, Lihong Liu, Jason T Kimata, Paul Zhou* GPI-anchored single chain Fv - an effective way to capture conformation-induced neutralization epitopes on HIV-1 envelope spike. Retrovirology 2010,7:79

  8.Hongbing Jiang, Shijian Zhang, Qiang Wang, Jinlan Wang, Liqing Geng, Tetsuya Toyoda*. Influenza virus genome C4 promoter/origin attenuates its transcription andreplication activity by the low polymerase recognition activity.Virology 2010, 408:190-196

  9.Wang W, Cavailler P, Ren P, Zhang J, Dong W, Yan H, Mardy S, Cailhol J, Buchy P, Sheng J, Fontanet A, Deubel V*. Molecular monitoring of causative viruses in child acute respiratory infection in endemo-epidemic situations in Shanghai. J Clin Virol. 2010 Nov;49(3):211-8. Epub 2010 Sep 19

  10.   Tao W, Xu C, Ding Q, Li R, Xiang Y, Chung J, Zhong J.A Single Point Mutation in E2 Enhances Hepatitis C Virus Infectivity and Alters Lipoprotein Association of Viral Particles Virology. 2009 Dec 5;395(1):67-76. Epub 2009 Sep 30.

五.实验室年报  

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