A newly-created Center of Excellence at Institut Pasteur Shanghai, supported by the Chinese Academy of Sciences and the City of Shanghai, recruits outstanding talents to comfort its research programs.   




  In the context of IPS, the Center for Microbes, Development and Health (CMDH) addresses the “post-modern, non-communicable epidemics” emerging in high-income regions, including high susceptibility of newborns to infections, and the developmental defects affecting populations in low-to-middle income regions, the focus being on the etiological role plaid by the ongoing global degradation of the human-microbial interface.  

  As a matter of fact, new-generation sequencing and bioinformatics have promoted the human gut microbiota to a position of significant driver of development, health and disease, hence the need to decipher the cross-talks established between commensal microorganisms at homeostasis and in disease states. Major challenges remain in defining the frontiers of the mutualistic symbiosis and to which extent it impacts on development, physiology and disease occurrence in case of dysbiosis. Hence the Center will mainly aim at establishing causality links by combining strong basic research set as “cellular microbiology” of the host-microbe mutualism, and clinical studies.  


  Our basic assumption is that it is during fetal life and the early post-natal period that the mother’s, then the child’s microbes can – directly or indirectly - most efficiently imprint on the fate of the baby through their capacity to sense, integrate and transmit positive and negative environmental influences. Understanding the physiological bases of this mutualistic symbiosis stemming from a long co-evolution between Homo sapiens and his microbes is prior to accessing to disease mechanisms.  


  Hence our multidisciplinary CMDH will largely focus on the time frame encompassing the first 1000 days of life that are critical to found body growth, immunity, neurodevelopment and health in general. In low-to-middle-income regions, poverty, malnutrition and sustained exposure to poor microbiological environments weaken this foundation with severe consequences such as earlier mortality and increased morbidities, loss of growth and altered neurodevelopmental potential. In high-income countries, the loss of traditional dietary rules and global hygiene (water, food), combined with uncontrolled use of antibiotics, alter the diversity of microbial taxa to which humans have been ancestrally exposed, hence creating conditions for increased incidence of asthma, allergy, obesity, diabetes, inflammatory bowel diseases and possibly some cancers.  


  CMDH will address three major lines of research Deciphering the basis of human gut microbiota maturation by ecological successions. This line will combine analyses of cohorts in collaboration with mother and child hospitals and basic microbiological studies analyzing the genetic, metabolic, nutritional and environmental constraints driving or altering its maturation and robustness.  

  (1) Understanding the role of the gut microbiota in maintaining a colonization barrier against pathogens.  

  (2) Evaluating the impact and deciphering the mechanisms by which the gut microbiota and its alterations affect, possibly program, child development, health and disease. 

  (3) Emphasis will be on impact on gut regeneration, immunological maturation, nutrition and metabolism, and brain development.  


  Cutting-edge technological platforms and animal facilities are available or will be further developed, particularly in imaging, metagenomics, metabolomics, culturomics and microfluidics / organ on chips / high-throughput screening.  


  With these aims, CMDH has already solidly established itself with a core of 13 group leaders and is concurrently actively recruiting in various areas to strengthen its expertise and establish a model of basic and translational multidisciplinary research offering ample opportunities for synergistic interactions.  


  CMDH was created with the strong belief that it needed an international base in order to foster the creation of an international network of collaborations. As a reflection of this aim, the 7 PIs who were recruited since CMDH opening came from UK, France, Singapore, USA, hence bringing their own network of international collaborations. In addition, several of the PIs from IPS that joined CMDH upon its creation brought solid international partnerships.  


  For more information about our Center, please visit our website: www.ips.ac.cn/CMDH  



  Prof. Philippe J. Sansonetti  

  Chief Scientist of the CMDH微生物、发育与健康研究中心首席科学家 


  Shanghai, China上海,中国 




















  (1) 通过生态演替来揭示人类肠道微生物群成熟的基础。该产品线将与母子医院合作对队列进行分析,并结合基础微生物学研究,分析驱动或改变其成熟度和健壮性的遗传,代谢,营养和环境限制。 

  (2) 了解肠道菌群在维持针对病原体的定殖屏障方面的作用。 

  (3) 评估肠道菌群影响对儿童发育,健康和疾病的影响并弄清其机制。其重点将放在对肠道再生,免疫系统的发育,营养和代谢以及大脑发育的影响上。 












  Prof. Philippe J. Sansonetti