The Center will address three major lines of research:

(1) Deciphering the basis of human gut microbiota maturation by ecological successions. This line will combine analyses of cohorts in collaboration with mother and child hospitals and basic microbiological studies analyzing the genetic, metabolic, nutritional and environmental constraints driving or altering its maturation and robustness.

(2) Understanding the role of the gut microbiota in maintaining a colonization barrier against pathogens.

(3) Evaluating the impact and deciphering the mechanisms by which the gut microbiota and its alterations affect, possibly program, child development, health and disease. Emphasis will be on impact on gut regeneration, immunological maturation, nutrition and metabolism, and brain development.

Cutting-edge technological platforms and animal facilities are available or will be further developed, particularly in imaging, metagenomics, metabolomics, culturomics and microfluidics / organ on chips / high-throughput screening.

With these aims, The Center for Microbes, Development and Health has already solidly established itself with a core of 12 group leaders and is concurrently actively recruiting in various areas to strengthen its expertise and establish a model of basic and translational multidisciplinary research offering ample opportunities for synergistic interactions.